Trifexis Chewable Tablets for Dogs: Effectiveness, Safety, and Side Effects

Trifexis is a widely recognized and controversial drug for dogs, achieving popularity for its FDA approval and the range of parasites it targets. Despite its notoriety due to reported side effects, Trifexis remains the number one prescribed combination parasite protection for dogs. It safeguards against fleas, heartworms, and intestinal worms. However, effectiveness does not always equate to safety for your canine companion.
What is Trifexis? Trifexis is a drug available in flavored chewable tablets for dogs, designed to protect them from parasites such as heartworms, roundworms, hookworms, and fleas. Administered monthly, Trifexis offers convenience with its beef-flavored tablet form, marketed as an easy method for monthly anti-parasite medication.


Trifexis is prescribed for killing fleas, preventing flea infestations, preventing heartworm disease, and treating and controlling adult hookworm, roundworm, and whipworm infection in dogs. The manufacturer claims Trifexis is safe for dogs at least 8 weeks old, though reported side effects are a concern.


What’s in Trifexis? The active ingredients in Trifexis, spinosad and milbemycin oxide, are designed to kill parasites and prevent heartworm disease. Spinosad belongs to the spinosyn class of insecticides found in over 80 registered pesticide products. It causes insects’ muscles to flex uncontrollably, leading to paralysis and death within 1-2 days. Milbemycin oxide works by binding to the chloride channels of parasites’ nerve and muscle cells, causing paralysis and death.


How Does Trifexis Work? Spinosad is the active ingredient in Trifexis that targets fleas, while milbemycin oxide is responsible for killing hookworms, roundworms, and whipworms and preventing heartworm disease. The paralysis of insects by these active ingredients can lead to risky side effects in dogs.


Side Effects Of Trifexis For Dogs The active ingredients in Trifexis have been linked to several reported side effects, many of which are neurological in nature, such as convulsions or ataxia. These side effects are particularly concerning for an oral drug, as they can persist in a dog’s system for at least 30 days after ingestion.


Many dog owners on social media have reported anecdotes blaming Trifexis for seizures and other neurological problems in dogs.


What’s the difference between Trifexis Green, Brown, and Blue? The recommended dosage for Trifexis depends on the size of the dog. They organize dosing recommendations by color, starting with pink for small dogs (5-10 lbs) and going up to brown for large breeds (60.1-120 lbs). If you decide to use the drug, ensure your vet prescribes the right one for your dog’s size to avoid giving more than needed.


Does your dog need Trifexis? Conventional veterinarians prescribe this drug for its convenience as it’s easy to give one pill a month to prevent fleas, intestinal worms, and heartworm disease. But is it really necessary to do this every month, year-round?


When it comes to pest preventive drugs, oral ones are the riskiest category for your dog. There are many safer options you can read about in the related article: The safest flea and tick prevention for dogs.


In many climates, fleas and heartworms are only a seasonal risk, not year-round. While preventing them is desirable, remember Trifexis also kills intestinal worms that your dog probably doesn’t have. There’s no reason to add unnecessary drugs to deworm your dog unless he actually has worms.


Now that you know the risks and reported side effects of Trifexis, if your veterinarian recommends the drug, think carefully and research safer alternatives before giving it to your dog.


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